Improving the heating efficiency of high intensity focused ultrasound ablation through the use of phase change nanodroplets and multifocus sonication.
PHYSICS IN MEDICINE AND BIOLOGY(2020)
摘要
Thermal ablation by ultrasound is being explored as a local therapy for cancers of soft tissue, such as the liver or breast. One challenge for these treatments are off-target effects, including heating outside of the intended region or skin burns. Improvements in heating efficiency can mitigate these undesired outcomes, and here, we describe methods for using phase-shift nanodroplets (PSNDs) with multi-focus sonications to enhance volumetric ablation and ablation efficiency at constant powers while increasing the pre-focal temperature by less than 6 degrees C. Multi-focus ablation with 4 foci performed the best and achieved a mean ablation volume of 120.2 +/- 22.4 mm(3) and ablation efficiency of 0.04 mm(3) J(-1) versus an ablation volume of 61.2 +/- 21.16 mm(3) and ablation efficiency of 0.02 mm(3) J(-1) in single focus case. The combined use of PSNDs with multi-focal ultrasound presented here is a new approach to increasing ablation efficiency while reducing off-target effects and could be generally applied in various focused ultrasound thermal ablation treatments.
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关键词
high intensity focused ultrasound,ablation,focal steering,phase-shift nanodroplets,non-invasive therapy
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