Genotoxicant exposure, activation of the aryl hydrocarbon receptor, and lipid peroxidation in cultured human alveolar type II A549 cells

Pavel Rossner,Helena Libalova,Kristyna Vrbova,Tereza Cervena,Andrea Rossnerova,Fatima Elzeinova,Alena Milcova,Zuzana Novakova,Jan Topinka

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2020）

引用 10|浏览19

暂无评分

摘要

•Processes associated with lipid peroxidation in A549 exposed to PAHs were studied.•BaP and organic extracts, but not 3-NBA, induced expression of CYP1A1 and CYP1B1.•BaP and 3-NBA induced lipid peroxidation; organic extracts inhibited this process.•Organic extracts reduce lipid peroxidation by an AhR-dependent mechanism.

查看译文

关键词

AA,AhR,BaP,CYP,DRE,EOM,IsoP,3-NBA,PAH,PG,PM2.5,PTGS-2,ROS

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要