Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells

Mia Levite,Daniel Zelig,Alon Friedman, Nili Ilouz,Raya Eilam,Zohar Bromberg,Ally Ahmed Ramadhan Lasu,Sagit Arbel-Alon,Shimon Edvardson, Mark Tarshish, Lul P. Riek,Richard Lino Lako,Benjamin Reubinoff,Mario Lebendiker,Dayana Yaish,Alexandra Stavsky,Eithan Galun

Journal of Autoimmunity（2020）

引用 16|浏览19

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摘要

Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoimmune antibodies.

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关键词

Epilepsy,Nodding syndrome,Onchocerciasis Associated Epilepsy (OAE),Autoimmune diseases,Autoimmune epilepsy,Dual-targeted autoimmune sword,Glutamate receptor antibodies,GluR3 antibodies,GluR3B peptide,GluR3B peptide antibodies,AMPA receptors,NMDA receptors,T cells

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