Rapid fabrication of versatile zwitterionic super-hydrophilic polymers by sole-monomer system for biomolecules separation

•Zwitterionic super-hydrophilic polymer is rapid fabrication via sole-monomer system.•The preparation strategy turns out to be very simple, time-saving and reproducible.•The polymer combines the advantages of phospholipid layer and hydrophilic material.•It exhibits excellent enrichment capacity for N-glycopeptides or C-reactive protein.•Binding sites of the polymer and C-reactive protein are explore for the first time.