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Differential Transthyretin Binding, Kinetic Stability and Additive Ex Vivo Stabilization by AG10 Compared to Tafamidis

Alan X. Ji,Paul W. Wong,Andreas Betz,Uma Sinha

Circulation（2019）

Cited 23|Views21
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Abstract
Introduction: Transthyretin (TTR) amyloidosis is a progressive, fatal disease. Dissociation of tetrameric TTR is the triggering event in the pathogenic mechanism; destabilizing TTR mutations accele...
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Key words
differential transthyretin binding,additive ex vivo stabilization,ag10,kinetic stability,tafamidis
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