MP01-18 HIGH PERFORMANCE OF 5-AMINOLEVULINIC ACID INDUCED FLUORESCENT URINE CYTOLOGY FOR DETECTING UROTHELIAL CARCINOMA

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology I (MP01)1 Apr 2020MP01-18 HIGH PERFORMANCE OF 5-AMINOLEVULINIC ACID INDUCED FLUORESCENT URINE CYTOLOGY FOR DETECTING UROTHELIAL CARCINOMA Gaku Yamamichi*, Wataru Nakata, Akihiro Yoshimura, Go Tsujimura, Yuichi Tsujimoto, Mikio Nin, Akihiro Mimura, Hideaki Miwa, and Masao Tsujihata Gaku Yamamichi*Gaku Yamamichi* More articles by this author , Wataru NakataWataru Nakata More articles by this author , Akihiro YoshimuraAkihiro Yoshimura More articles by this author , Go TsujimuraGo Tsujimura More articles by this author , Yuichi TsujimotoYuichi Tsujimoto More articles by this author , Mikio NinMikio Nin More articles by this author , Akihiro MimuraAkihiro Mimura More articles by this author , Hideaki MiwaHideaki Miwa More articles by this author , and Masao TsujihataMasao Tsujihata More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000815.018AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Generally, voiding urine cytology is problematic because of its low sensitivity for detecting urothelial carcinoma (UC) in clinical practice. To improve the sensitivity, we focused on 5-aminolevulinic acid (5-ALA) and photodynamic diagnosis. Recent studies suggest 5-ALA induced fluorescent urine cytology is more sensitive than conventional urine cytology especially for only low grade UC, but it is high grade UC rather than low grade UC that threatens our lives. In this study, we evaluated the diagnostic efficacy of 5-ALA induced fluorescent urine cytology on large number of UC. METHODS: Total 499 patients, consisting of 189 non-cancer patients, 188 bladder tumor (BT) patients and 122 upper urinary tract urothelial carcinoma (UUT-UC) patients from March 2013 to September 2019 in our institute, were included in this study. Before transurethral resection of BT or nephroureterectomy, using the same voided urine sample, we compared the sensitivity and specificity between conventional urine cytology and 5-ALA induced fluorescent urine cytology. RESULTS: Over all, the sensitivity of 5-ALA induced fluorescent urine cytology was significantly high compared to conventional urine cytology (82.9% vs 65.8%; p<0.001) and the specificity were equivalent high (93.7% vs 93.7%; p=1.0). In subgroup analysis, theses high sensitivity of 5-ALA induced fluorescent urine cytology were also detected regardless of age, gender, tumor type (BT and UUT-UC), pT stage and tumor grade. CONCLUSIONS: The 5-ALA induced fluorescent voiding urine cytology is significantly effective compared to conventional cytology for UC diagnosis and is very useful tool for clinical use. This is the first large scale study indicating the utility of the 5-ALA induced fluorescent urine cytology for high grade UC. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e9-e9 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gaku Yamamichi* More articles by this author Wataru Nakata More articles by this author Akihiro Yoshimura More articles by this author Go Tsujimura More articles by this author Yuichi Tsujimoto More articles by this author Mikio Nin More articles by this author Akihiro Mimura More articles by this author Hideaki Miwa More articles by this author Masao Tsujihata More articles by this author Expand All Advertisement PDF downloadLoading ...