High mobility group box-1 protects against Aflatoxin G 1 -induced pulmonary epithelial cell damage in the lung inflammatory environment.

Lifei Kang,Ningfei Guo,Xiaoyi Liu,Xiuqing Wang,Wenli Guo,Shelly M Xie,Chunping Liu,Ping Lv,Lingxiao Xing,Xianghong Zhang,Haitao Shen

Toxicology Letters（2020）

引用 8|浏览36

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摘要

•Upregulation of HMGB1 was observed in AFG1-induced lung inflamed tissues.•AFG1-induced TNF-α-dependent inflammation regulates HMGB1 upregulation in vivo.•AFG1 enhanced cytosolic translocation and secretion of HMGB1 in Beas-2b cells.•The addition of extracellular soluble HMGB1 protected AFG1-induced DNA damage.•Blockade endogenous HMGB1 by siRNA significantly enhanced AFG1-induced damage.

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关键词

Aflatoxin,High mobility group box-1,TNF-α,Lung inflammation,DNA damage

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