Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression.

•rs12415800 of the silent mating type information regulation 2 homolog 1 gene (SIRT1 is a promising candidate genetic locus for depression.•166 cases with first-episode medication-naïve major depression and 166 sex and age matched healthy controls were collected to explore the impact of rs12415800 genotypes on gray matter volumes among different brain regions.•the risk allele A of rs12415800 (GA/AA) may be associated gray matter volume deficits in right frontal superior, right precuneus, and left precuneus/cuneus only in patients with MDD, not in controls.