The synergistic effect of NELL1 and adipose-derived stem cells on promoting bone formation in osteogenesis imperfecta treatment.

Biomedicine & Pharmacotherapy(2020)

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摘要
•Nell1 gene modification significantly enhanced osteogenic differentiation of ADSCs.•Systemically infused lenti-Nell1-ADSCs participated in bone formation.•rmNELL1 combined with ADSCs or lenti-Nell1-ADSCs markedly promoted bone formation.
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关键词
NELL1,Adipose-derived stem cells,Lentivirus,Osteogenesis,Osteogenesis imperfecta
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