Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Delong Chen,Zhen Ye,Chao Wang,Qingqing Wang,Haibin Wang,Vincent Kuek,Ziyi Wang,Heng Qiu,Jinbo Yuan,Jacob Kenny,Fan Yang,Jianbo He,Yun Liu,Gang Wang,Meng Zhang,Gangyu Zhang,Junjian Wang,Peng Chen,Jiake Xu

Pharmacological Research（2020）

引用 29|浏览77

暂无评分

摘要

Note: ARC inhibits osteoclastogenesis by suppressing RANKL-induced MAPK (including JNKs and ERKs), calcium, and NFATc1 signaling pathway, as well as by promoting the expression of ROS scavenging enzymes in Nrf2/Keap1/ARE signaling pathway.

查看译文

关键词

α-MEM,ARC,ARE,Atp6V0d2,BMMs,BSA,BV/TV,Ct.Ar,Ct.Ar/Tt.Ar,Ct.Th,Ctsk,DMSO,EDTA,FBS,Gsr,H&E,Ho-1,IL-1,Keap1,MAPK,M-CSF,Mmp9,MTS,NFATc1,NF-κB,Nrf2,N.Oc/BS,OVX,Oc.S/BS,PFA,qRT-PCR,RANK,RANKL,RIPA,ROS,SDS-PAGE,Tb.Th,Tb.Sp,Tb.N,Tt.Ar,TGF-β,TRAcP,TRAF6

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要