The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients.

•The current largest register-based study in Eastern Denmark of HPV-tested Oropharyngeal Squamous Cell Carcinoma (OPSCC).•All confirmed OPSCC cases (n= 2169) from 2000-2017 were included and tested for HPV DNA and p16 expression.•HPV-positive tumours had the viral DNA genotyped (n= 770) to examine high-risk genotypes.•HPV16 was the most common genotype (86%) among HPV-positive cases.•The incidence rate of OPSCC increased threefold overall, especially for HPV-positive OPSCC of the tonsils.