Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition

Han Su

Heng Zeng

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Bo Liu

Jian-Xiong Chen

Journal of cellular and molecular medicine, 2020.

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Keywords:

cardiac dysfunctionfibrosishypertensionpericytesreactive oxygen speciesMore(2+)

Abstract:

Hypertension is the key factor for the development of cardiac fibrosis and diastolic dysfunction. Our previous study showed that knockout of sirtuin 3 (SIRT3) resulted in diastolic dysfunction in mice. In the present study, we explored the role of SIRT3 in angiotensin II (Ang-II)-induced cardiac fibrosis and pericyte-myofibroblast transit...More

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