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The Receptor-Binding Domain of the Viral Spike Protein is an Immunodominant and Highly Specific Target of Antibodies in SARS-CoV-2 Patients

Lakshmanane Premkumar,Bruno Segovia-Chumbez,Ramesh Jadi,David R. Martinez,Rajendra Raut,Alena J. Markmann,Caleb Cornaby,Luther Bartelt,Susan Weiss,Yara Park,Caitlin E. Edwards,Eric Weimer,Erin M. Scherer,Nadine Rouphael,Srilatha Edupuganti,Daniela Weiskopf,Longping V. Tse,Yixuan J. Hou,David Margolis,Alessandro Sette,Matthew H. Collins,John Schmitz,Ralph S. Baric,Aravinda M. de Silva

Science immunology（2020）

引用 755|浏览47
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摘要
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.
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关键词
spike protein
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