Amyloid-β oligomerization monitored by single-molecule stepwise photobleaching

Lara Dresser,Patrick Hunter, Fatima Yendybayeva,Alex L Hargreaves,Jamieson A L Howard,Gareth J O Evans,Mark C Leake,Steven D Quinn

Methods（2021）

引用 24|浏览12

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摘要

•Method enables investigation of amyloid-β oligomer stoichiometry without requiring extrinsic fluorescent probes.•Uses single-molecule stepwise photobleaching in vitro.•Unveils heterogeneity within populations of oligomers.•Assays oligomer-induced dysregulation of intracellular Ca2+ homeostasis in living cells.

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关键词

Single-molecule TIRF,Photobleaching,Amyloid oligomerization,Calcium sensing,Fluorescence

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