The muscarinic M 1 receptor modulates associative learning and memory in psychotic disorders.

Geor Bakker,Claudia Vingerhoets,Oswald J N Bloemen,Barbara J Sahakian,Jan Booij,Matthan W A Caan,Thérèse A M J van Amelsvoort

NeuroImage: Clinical（2020）

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摘要

•Psychosis characterised by different M1 sensitivity in learning and memory.•Greater limbic-temporal hyperactivity in response to biperiden in psychosis.•Hippocampal M1 binding predicted limbic-temporal hyperactivation underlying learning.•M1 agonist may normalise functional response underlying learning & memory in psychosis.

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muscarinic m1 receptor modulates,psychotic disorders,memory

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