Suppressive activities of mangiferin on human epithelial ovarian cancer

•Mangiferin suppresses tumor progression in in-vivo experiments with no side effects.•Mangiferin inhibits the metastasis of epithelial ovarian cancer by down-regulating MMP2 and MMP9.•Mangiferin reduces the number of epithelial ovarian cancer cells at a relative low concentration and shows a significant inhibitory effect in clear cell carcinoma than paclitaxel in a high concentration.