Trajectories of depressive symptoms through adolescence as predictors of cortical thickness in the orbitofrontal cortex: An examination of sex differences.

•Reduced CT in the OFC has been observed in MDD, but when/how this emerges is unclear.•Effects of MDD symptom trajectories in adolescence on CT in the OFC were examined.•No main effects of adolescent trajectories of MDD symptoms on CT were found.•The effect of symptom slope on CT was moderated by sex.