Zacopride exerts an antiarrhythmic effect by specifically stimulating the cardiac inward rectifier potassium current in rabbits: exploration of a new antiarrhythmic strategy
CURRENT PHARMACEUTICAL DESIGN, pp. 5746-5754, 2020.
Background: Zacopride, a potent antagonist of 5-HT3 receptors and an agonist of 5-HT4 receptors, is a gastrointestinal prokinetic agent. In a previous study, we discovered that zacopride selectively stimulated the inward rectifier potassium current (I-KI) in the rat and that agonizing I-K1 prevented or eliminated aconitine-induced arrhyth...More
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