Zacopride exerts an antiarrhythmic effect by specifically stimulating the cardiac inward rectifier potassium current in rabbits: exploration of a new antiarrhythmic strategy

Yuanyuan Lin
Yuanyuan Lin
Junhu Li
Junhu Li
Baozhong Zhu
Baozhong Zhu
Qinghua Liu
Qinghua Liu
Xiaojie Bai
Xiaojie Bai
Bingmei Chang
Bingmei Chang
Yanlin Guo
Yanlin Guo
Xuewen Li
Xuewen Li
Jimin Cao
Jimin Cao

CURRENT PHARMACEUTICAL DESIGN, pp. 5746-5754, 2020.

Cited by: 0|Views4
WOS

Abstract:

Background: Zacopride, a potent antagonist of 5-HT3 receptors and an agonist of 5-HT4 receptors, is a gastrointestinal prokinetic agent. In a previous study, we discovered that zacopride selectively stimulated the inward rectifier potassium current (I-KI) in the rat and that agonizing I-K1 prevented or eliminated aconitine-induced arrhyth...More

Code:

Data:

Get fulltext within 24h
Bibtex
Your rating :
0

 

Tags
Comments