A New Prenylated Coumestan from the Roots of Campylotropis Hirtella

A new prenylated coumestan, campylohirtin A (1), along with fifteen phenolic known compounds (2-16) and four other known compounds (17-20), was obtained from the 95% ethanol extract of roots of Campylotropis hirtella. Their structures were elucidated based on extensive spectroscopic analysis (1 D and 2 D-NMR, MS, UV and IR). In vitro antimalarial activities of compounds 1-3,5-14 and 16 were evaluated by beta-hematin formation inhibition assay. Compared with the positive control chloroquine diphosphate, compounds8,11and16exhibited strong antimalarial activity with the IC50 values of 69.9, 33.2 and 75.4 mu M, respectively. Compounds 1-3,5-7 and 12 showed moderate antimalarial activities with IC50 values ranging from 134.6 mu M to 578.6 mu M. [GRAPHICS] .