BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway.

Bin Xu,Chun-Xia Gan,Si-Si Chen,Jia-Qi Li,Ming-Zhuo Liu,Guang-Hua Guo

Life Sciences（2020）

引用 27|浏览2

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摘要

Collectively, these results indicate that BMSC-derived exosomes can effectively alleviate smoke inhalation lung injury by inhibiting the HMGB1/NF-κB pathway, suggesting that exosome, a noncellular therapy, is a potential therapeutic strategy for inhalation lung injury.

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关键词

Exosome,Smoke inhalation,Lung injury,HMGB1,Mesenchymal stem cell

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