Downregulation of microRNA-155-5p prevents immune thrombocytopenia by promoting macrophage M2 polarization via the SOCS1-dependent PD1/PDL1 pathway.

Yuying Chang,Xi Chen,Yaoyao Tian,Xinyu Gao,Zhiyu Liu,Xiushuai Dong,Lianjie Wang, Fei He,Jin Zhou

Life Sciences（2020）

引用 17|浏览1

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摘要

Silencing of miR-155-5p could promote PD1/PDL1 pathway-mediated macrophage M2 polarization and prevent ITP via up-regulation of SOCS1, thus relieving ITP.

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关键词

microRNA-155-5p,SOCS1,Immune thrombocytopenia,Macrophage M2 polarization,Peripheral blood mononuclear cell

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