MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma.

Caterina Brighi,Lee Reid,Alison L White,Laura A Genovesi,Marija Kojic,Amanda Millar,Zara Bruce,Bryan W Day,Stephen Rose,Andrew K Whittaker,Simon Puttick

Neuro-oncology advances（2020）

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摘要

FUS exposure successfully allowed temporary BBB disruption, localized to specifically targeted, nonenhancing, infiltrating tumor regions and delivery of a systemically administered antibody was significantly increased.

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关键词

MRI,blood,brain barrier,focused ultrasound,high-grade glioma,vasculature permeability

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