Thiosemicarbazone and Benzimidazole Hybrid Molecules: The Privileged Scaffolds for Anti-Bacterial Activity

Ten thiosemicarbazones and Benzimidazole Hybrid molecules were synthesized and purified to investigate antibacterial activity. MIC values of the compounds were determined by the Cup borer method against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and streptococcus pneumonia. 2MOQ is an important target for antibacterial drugs. Despite the development of resistance against 2MOQ inhibitors drugs, there is still significant potential for designing new chemical entity with affordable, safe and efficacious antibacterials. In present study thiosemicarbazonebenzimidazole hybrids were designed and interaction of these conjugate hybrids was investigated by docking studies in the binding site of PDB ID: 2MOQ using Glide v 5.6. Among the series of designed compounds five compounds with good potential were synthesized. Structural confirmation of these compounds was done by FT-IR, 1H-NMR and Mass spectroscopy. The activity of compound AD2, AD3, AD7, AD8 and AD10 was found to be good against various strains. The above study could be very useful for further design and development of new antibacterials.