Inhibition of Fibrosis Decreases the Pathology of Lymphedema

PURPOSE: Lymphedema is characterized by fibrosis, and there is accumulating evidence that this process plays a key role in the pathology of the disease. We have previously shown that the expression of the profibrotic growth factor transforming growth factor (TGF)-β is increased in lymphedematous tissues. The purpose of this study was to evaluate the efficacy of this topical compound for prevention and treatment of lymphedema.