Radioimmunotherapy : A New Treatment Modality for B-Cell Non-Hodgkin ’ s Lymphoma

We applaud Ghobrial and Witzig for their comprehensive and balanced article on "Radioimmunotherapy: A New Treatment Modality for B-cell NonHodgkin's Lymphoma." These authors have provided a review that will serve the oncologist and oncology patient well. They have not engaged in arcane and tedious discussion of which anti-CD20 monoclonal antibody (ibritumomab tiuxetan [Zevalin] or tositumomab/iodine-131 [I-131] tositumomab [Bexxar]), or radionuclide (yttrium-90 [Y-90] or I-131), or dosing method is better. Wisely, Ghobrial and Witzig have provided accurate distillates of the many publications on these exciting drugs. Because no rigorous body of data clearly indicates that one drug is better than the other, these debates only confuse the oncologist and are better left to the "technocrat."