Single Nucleotide Polymorphisms in miR-149 ( rs 2292832 ) and miR-1011 ( rs 7536540 ) Are Not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection

Hepatitis B virus infection is the most common risk factor for cirrhosis and liver cancer. Liver cancer ranked the fifth most common cancer in the world (Jemal et al., 2011). Considerably, chronic hepatitis B virus can cause at least 60% of circumstance of liver cancer. Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. The highest prevalence of liver cancer can be found in East, the middle zone of Eastern Asia and in sub-Saharan Africa (El-Serag et al., 2007). HCC is the most frequent subtype of the liver cancer which accounts for 70-85% (Perz et al., 2006). Single nucleotide polymorphism (SNP) is one of many mechanisms accounted for genetic variation in human, described by a single-nucleotide substitution of one base into another in DNA sequences. The abnormal forms of SNPs were recorded that SNPs on coding region can