NEIL 3 variant rs 12645561 is in association with the prognosis of glioma in Chinese Han population of Xi ’ an

NEIL3 may affect the development of glioma. However, few previous studies evaluated the function of NEIL3 in the prognosis of patients with glioma. The characteristics of age (≥40) had a significantly increased risk of death (HR: 1.302, 95% CI: 1.010-1.678, P=0.041), by contrast, the surgical operation (subtotal tumour resection, GTR) and chemotherapy were the protective factors which decreased risk of death (HR: 0.645, 95% CI: 0.492-0.845, P<0.05; HR: 0.755, 95% CI: 0.580-0.984, P<0.05). The genotype (T/T) of rs12645561 had a significantly increased risk of death (HR: 2.123, 95% CI: 1.099-4.104, P=0.043). After HR was adjusted with chemotherapy and surgical operation, the T/T genotype of rs12645561 increased risk of glioma death (HR: 1.808, 95% CI: 1.071-3.051, P=0.027). If HR was adjusted with chemotherapy, surgical operation, the minor allele T/T significantly increased risk of astrocytoma death (HR: 2.528, 95% CI: 1.292-4.947, P=0.007). Our results suggest that the polymorphisms of rs12645561 in NEIL3 may predict overall survival of glioma.