Post-translational modification of VSV glycoprotein , but not JNK 1 inhibition , is the antiviral mechanism of SP 600125 2 3

3 Sabrina Marozin, Jennifer Altomonte, Sibylle Apfel, Phat X. Dinh, Enrico N. De Toni, 4 Antonia Rizzani, Andreas Nüssler, Nobuyuki Kato, Roland M. Schmid, Asit K. Pattnaik 5 and Oliver Ebert 6 7 Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany; 8 School of Veterinary Medicine and Biomedical Sciences & the Nebraska Center for Virology, 9 University of Nebraska-Lincoln, Lincoln, USA; Department of Medicine 2, University Hospital 10 Grosshadern, University of Munich, Germany; Department of Traumatology, Klinikum rechts 11 der Isar, Technical University of Munich, Germany; Department of Molecular Biology, 12 Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 13 Japan 14 15 To whom correspondence may be addressed: Oliver Ebert, Department of Medicine, 16 Klinikum rechts der Isar, Technical University of Munich, Trogerstr. 32, 81675 Munich, 17 Germany. Tel: +49-89 41402261. Fax: +49-89-41402258. Email: oliver.ebert@lrz.tum.de 18 19