Oltipraz provides protectio to swiss albi o mice agai st gamma radiatio

In the present study Radiation protection from Oltipraz (5-[2-pyrazinyl]-4-methyl-1, 2-dithiol-3-thione) has been evaluated in Swiss albino mice. The oral administration of Oltipraz (100 mg/kg/day dissolved in 10% Tween 80) was given to 6-8 week old Swiss albino mice (25±2gm) for 2 consecutive days prior to irradiation. A regression analysis of survival data yielded LD50/30 as 5.82 and 8.38 Gy for the control (radiation alone) and experimental (Oltipraz + radiation) groups, respectively, yielding a dose reduction factor of 1.44. The results of the present study suggest that Oltipraz provides protection against gamma radiation induced alterations in Swiss albino mice.