Running Title : ExoU and ExoY induce endothelial proteinopathy 1 1 2 Pseudomonas aeruginosa exoenzymes U and Y induce a 3 transmissible endothelial proteinopathy 4 5

K. Adam Morrow, Cristhiaan D. Ochoa, Ron Balczon, Chun Zhou, Laura Cauthen, 6 Mikhail Alexeyev, Katherine M. Schmalzer, Dara W. Frank, and Troy Stevens 7 8 Departments of Physiology and Cell Biology, Biochemistry and Molecular Biology, and 9 Medicine, Center for Lung Biology, University of South Alabama, Mobile AL 36688; Physician10 Scientist Training Program, Department of Medicine and Division of Pulmonary and Critical 11 Care, University of Texas-Southwestern Medical Center, Dallas TX 75390; Department of 12 Medicine, Division of Hematology/Oncology, Department of Microbiology and Molecular 13 Genetics, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee 14 WI 53226 15 16 17