Comparative pharmacology of AMR-MCH-1 and AMR-MCH-2 , MCH 1 receptor antagonists for the treatment of obesity

Bruce Sargent, Matthew Surman,Emily Freeman, James Grabowski,Xiao-Wu Jiang,Guowei Jiang,Mark Hadden, Michele Luche,Yuri Khmelnitsky,John Lindsay, Lyuda Mozhaeva,Julianne Zaremba, Jean Viggers, Steve Vickers, Simon Goddard,Sharon Cheetham, Peter Guzzo

semanticscholar（2008）

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摘要

Melanin-concentrating hormone (MCH) is a cyclic, 19 amino acid neuropeptide. In mammals, MCH is highly expressed in the zona incerta and lateral hypothalamus and regulates food intake and energy homeostasis through interaction with the MCH1 receptor (Collins, et al., 2003; Skofitsch et al., 1985). Antagonists of the MCH1 receptor have been shown to be a promising new approach for the treatment of obesity (Collins, et al., 2003; McBriar, 2006).

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