TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and Mei- P26, leads to tumorous phenotypes in neural and germline stem cell

TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and MeiP26, leads to tumorous phenotypes in neural and germline stem cell lineages, respectively. These phenotypes are caused, at least in part, by the expression of dMyc. Here, the authors show that in the wing epithelium, dMyc overexpression or Brat depletion do not cause tissue overgrowth because Mei-P26 is up-regulated. Thus, Brat and Mei-P26 act as context-dependent tumor suppressors.