Identification of immunogenic T-cell peptides of Mycobacterium tuberculosis PE_PGRS33 protein.

David Ortega-Tirado,Esmeralda Ivonne Niño-Padilla,Aldo A Arvizu-Flores,Carlos Velazquez,Clara Espitia,Carmen J Serrano,José Antonio Enciso-Moreno,Adriana Sumoza-Toledo,Adriana Garibay-Escobar

Molecular Immunology（2020）

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摘要

•Five immunogenic T-cell peptides of PE_PGRS33 were identified by bioinformatics.•Immunogenic T-cell peptides of PE_PGRS33 cross-react with HLA class II molecules.•Immunogenic T-cell peptides of PE_PGRS33 show a global population coverage >50 %.•Immunogenic peptides induced IFN-γ by PBMC from household contacts of TB patients.

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关键词

Mtb,TB,MOE,PDB,HEL,BLAST

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