Mania Associated With Supratherapeutic Tacrolimus Levels in a Patient With No Psychiatric History

Abstract Neurological side effects of tacrolimus have been well documented in the literature, while psychiatric symptomatology, especially mania, have rarely been reported. We report the case of a 64 year old man with no psychiatric history who developed mania with supratherapeutic serum concentrations of tacrolimus. The patient was treated with a mood stabilizer and an atypical antipsychotic while tacrolimus was discontinued and his other immunosuppressants were continued.