Histone deacetylase inhibition by MS-275 potentiates glucose-stimulated insulin secretion without affecting glucose oxidation

•MS-275 pretreatment significantly potentiated insulin secretion from rat islets.•Cacna1g and Adcy1 genes were up-regulated in MS-275-treated islets.•Knockdown of HDAC1 elevated Cacna1g and Adcy1 expressions in rat islets.•MS-275 increased H3K27 acetylation levels of Cacna1g and Adcy1 genes.•MS-275 had no effect on glucose-induced oxygen consumption rate in islets.