Two New Sesquiterpenes from the Stems of Miliusa Velutina

From the ethyl acetate extract of the stems ofMiliusa velutina, seven compounds (1-7) were isolated, including two new compounds such as mivelutina A acid (1), mivelutina B acid (2) and one known compound mivelutina B methyl ester (3). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis. The absolute configuartions were determined based on DFT calculations of(13)C chemical shifts. All of the seven compounds were screened for theirin vitrocytotoxic activities against HepG2 cell line using the SRB assay. Epoxyconiferyl alcohol (7) showed the highest potential for the cytotoxicity of cancer cell lines HepG2 with the IC(50)values of 95.94 mu g/mL (527 mu M).