Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders.

Yuan Qi, Li-Sha Chou,Lin-Jie Zhang,Ming-Qi Liu,Ming Yi,Qiu-Xia Zhang,Jing Wang,Ting Li,Da-Qi Zhang,Li Yang

Multiple Sclerosis and Related Disorders（2020）

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摘要

•Patients with NMOSD had significantly higher CSF YKL-40 levels.•CSF YKL-40 positively correlated with the expanded disability status scale scores.•YKL-40 could be a severity biomarker and a potential target for NMOSD treatment.

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关键词

YKL-40,Neuromyelitis optica spectrum disorders,Inflammation,Astrocytes

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