Intestinal expression of toll-like receptor gene changes early after gastric bypass surgery and association with type 2 diabetes remission.

•In obesity models, abnormal toll-like receptor (TLR) activation by dysbiosis increases gut permeability•Gut dysbiosis and permeability have been associated with chronic inflammation in type 2 diabetes•Roux-en-Y gastric bypass (RYGB) surgery influences gut microbiota and can lead to the remission of obesity-related type 2 diabetes•Decreases in gut TLR-4 and TLR-7 expression were observed after RYGB surgery•Decreased gut TLR expression may be enrolled in post-RYGB surgery glycemic homeostasis