IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay

Peiqi Wu
Peiqi Wu
Rui Su
Rui Su
Chunqing Yang
Chunqing Yang
Di Wang
Di Wang
Xuelei Ruan
Xuelei Ruan
Jian Zheng
Jian Zheng
Yang Yang
Yang Yang

RNA BIOLOGY, pp. 1777-1788, 2020.

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Abstract:

Blood-tumour barrier (BTB) has been known to significantly attenuate the efficacy of chemotherapy for glioma. In this report, we identified that insulin-like grown factor 2 mRNA-binding protein 2 (IGF2BP2) was over-expressed in glioma microvessel and glioma endothelial cells (GECs). Knockdown of IGF2BP2 decreased the expression of lncRNA ...More

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