Artesunate reverses LPS tolerance by promoting ULK1-mediated autophagy through interference with the CaMKII-IP3R-CaMKKβ pathway
International Immunopharmacology(2020)
摘要
•Artesunate reverses LPS tolerance by recovering the impaired autophagy in vitro and in vivo.•Artesunate promotes autophagy by activating ULK1 via attenuation of the excessive AMPK activation.•Artesunate interfering with the CaMKII-IP3R-CaMKKβ pathway to inhibit AMPK activation.
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关键词
Artesunate,LPS tolerance,Autophagy,ULK1,AMPK,Ca2+
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