MRGPRX2 Activation Causes Increased Skin Reactivity in Patients with Chronic Spontaneous Urticaria.

Maria Shtessel,Nathachit Limjunyawong,Eric T Oliver,Kristin Chichester,Li Gao,Xinzhong Dong,Sarbjit S Saini

The Journal of investigative dermatology（2020）

引用 38|浏览18

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摘要

We present heightened skin reactivity in vivo to two MRGPRX2 drug ligands in patients with chronic spontaneous urticaria. Selectivity for the MRGPRX2 pathway by drug ligands was demonstrated by the loss of drug activation in MRGPRX2-KO LAD2 cells.

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