Identification and signaling characterization of four urotensin II receptor subtypes in the western clawed frog, Xenopus tropicalis

Norifumi Konno, Moe Takano,Koichi Miura,Mikiya Miyazato,Tomoya Nakamachi,Kouhei Matsuda,Hiroyuki Kaiya

General and Comparative Endocrinology（2020）

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摘要

•Four functional UTR (UTR1, UTR3, UTR4, and UTR5) subtypes are present in X. tropicalis.•UTR1 and UTR5 are most likely linked to PLC/PKC and GEF-H1/RhoA/ROCK/MLC signaling.•UTR3 and UTR4 are likely linked to GEF-H1/RhoA/ROCK/MLC signaling via the G12/13 protein.•Similarity between Xenopus UTR1 and UTR5 suggests that local duplication might have occurred.

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关键词

Urotensin II,Urotensin II receptor subtypes,Signaling pathway,Xenopus tropicalis

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