SARS-CoV-2 IgG and IgA antibody response is gender dependent; and IgG antibodies rapidly decline early on

Serology is an important pillar in the diagnostics of SARS-CoV-2 infection, especially when PCR may no longer be positive. We thus read with interest the recent report by Tré-Hardy et al.1 on SARS-CoV-2 serology three weeks into COVID-19. With new data from a longitudinal cohort study, we here complement this knowledge by following patients up to 10 weeks after proven SARS-CoV-2 infection. The obtained serological measurements suggested rapidly declining levels of IgG antibodies against the virus spike (SP) and nucleocapsid (NC) proteins as well as strong gender-specific characteristics of both IgG and IgA antibody levels against the virus SP.