Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex

Neuroscience(2020)

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摘要
•Excitatory transmission is preserved in glutamine transporter SN1 depleted mouse frontal cortex.•SN1 transporter loss resulted in a centrally located unaltered number of synaptic vesicles.•SN1 transporter depletion resulted in the unchanged length of the active zone in synapses.•Synaptic proteins synaptophysin, synaptotagmin, and vit1A weren’t affected by SN1 decrease.
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关键词
Electrophysiology,Glutamatergic transmission,Slc38a3 transporter,Glutamine,Vivo-morpholino,Synaptic vesicles
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