Caution With The Use Of Lopinavir/Ritonavir In Severely Ill Patients For The Treatment Of Sars-Cov-2: A Report Of Severe Jaundice

INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus.METHODS: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group.RESULTS: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%).DISCUSSION: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.