Three Regioselectively Acylated Flavonoid Aglycone Derivatives in Equimolar Yield at One Blow

Eleni Kyriakou,Androniki D Kostagianni,Tahsin F Kellici,Efstathia Giannopoulou,Konstantinos E Siatis,Nisar Sayyad,Haralabos P Kalofonos, Thomas Mavromoustakos,Haralambos Stamatis,Andreas G Tzakos

CHEMISTRYSELECT（2018）

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摘要

A simple and time-effective chemoenzymatic process to obtain three regioselective acylated quercetin analogues in a 1:1:1 ratio in one pot is described. This process overcomes the inherent scaffold intricacy and synthetic complexity of quercetin. Cell proliferation experiments in three breast cancers cell lines pinpoint the high potency of the generated compounds.

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关键词

Biocatalysis,Cancer,Quercetin,In Silico Studies,NMR experiments,Regioselectivity

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