Candidate mechanisms linking insomnia disorder to Alzheimer’s disease risk

•Insomnia disorder increases Alzheimer’s disease risk; hyperarousal features of insomnia may contribute to this relationship.•Physiological, cortical, and cognitive-emotional hyperarousal may act on core mechanisms driving AD pathophysiology.•Objective short sleep and circadian rhythm disruptions may act as additional compounding pathways exacerbating AD pathophysiology.