Double-Sensitive Drug Release System Based On Mno2 Assembled Upconversion Nanoconstruct For Double-Model Guided Chemotherapy
ACS APPLIED NANO MATERIALS(2018)
摘要
A double-sensitive drug release system based on MnO2 nanosheets was synthesized using a facile method for imaging guided chemotherapy in cancer cells. The upconversion nanoparticles (UCNPs) as core are used for upconversion luminescence (UCL) imaging, and the coating of mesoporous silica shows excellent ability for loading drug. The assembly with MnO2 nanosheets can respond to low intracellular pH and GSH in cancer cells. The obtained UCNPs@ mSiO(2)-MnO2 nanoparticles with excellent biocompatibility can be applied as drug carriers. As expected, the UCNPs@mSiO(2)(DOX) MnO2 (UCDMs) nanoconstruct loading with DOX offer practical chemotherapeutic effects in vitro, suggesting the active drug release in cancer cells. The luminescence intensity and magnetic resonance signals increased with the decomposition of the MnO2 nanosheets and the release of DOX under low pH and high levels of GSH. In addition, the UCDMs exhibit excellent intracellular UCL imaging, indicating that they can be used as a selective imaging agent in a cancerous environment. Thus, the UCDMs present potential application for use as theranostic agents in imaging guided therapy.
更多查看译文
关键词
upconversion nanoparticles,MnO2 nanosheets,pH/GSH sensitive,drug release,UCL/MR imaging
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要