Stimulation Of Oral Mucosal Regeneration By Low Intensity Pulsed Ultrasound: An In Vivo Study In A Porcine Model

Purpose: Many studies have shown the ability of low intensity pulsed ultrasound (LIPUS) to stimulate the bone, cartilage and tendon regeneration but only a few studied LIPUS interest in the regeneration of the oral mucosa. The purpose of this study is to assess the ability of LIPUS to stimulate the regeneration of the palatal mucosa in a porcine model.Methods: Ten adults mini-pigs were used. Two mucosal wounds were realised on the left and right side of the palate of each pig. The right side was treated with LIPUS at 1 MHz of frequency and 300 mW/cm(2) of acoustic intensity. The left side was not treated. The morphology of the wound was evaluated using a polymer silicone molding.Results: The difference between two sides was significant from day 7 with a p value <0.0001. At day 21, the wound is completely healed on all pigs with LIPUS. The control soft tissue defect exposed a healing of 80%.Conclusions: The present study showed that the use of LIPUS on the oral mucosa accelerates the healing of the masticatory mucosa.