ANALYSIS OF THE DIAGNOSIS, TREATMENT AND PROGNOSIS OF SOLID PSEUDOPAPILLARY TUMOURS OF THE PANCREAS

Objective: To explore the diagnosis, treatment and prognosis of solid pseudopapillary tumours of the pancreas to establish a more standardized diagnosis and treatment process by analysing the clinical features. Methods: Clinical data of 38 patients with solid pseudopapillary tumour of the pancreas confirmed by pathology after surgery from January 01, 2005 to December 30, 2018 was analysed retrospectively to summarize the clinical features, treatment methods and prognosis, and all patients were followed up. Results: Among the 38 cases, there were 6 males and 32 females with an average age of 29.4 +/- 11.1(12-54) years old. All patients underwent surgical treatment. Based on the findings of intraoperative explorations of the tumour location, the surgical procedures included pancreaticoduodenectomy, pyloric pancreaticoduodenectomy, pancreatic head resection for duodenum, laparoscopic pancreatic tail resection, (laparoscopic) pancreas body-tail resection and splenectomy, pancreatic interruption, and local tumour resection. Except for one case in which the follow-up data was lost, the remaining 37 cases were followed up to date. One patient relapsed after 3 months but has survived 53 months after reoperation with no recurrence and metastasis. The remaining patients did not relapse or metastasise. Conclusion: The incidence rate of solid pseudopapillary tumour of the pancreas is low but has increased significantly in recent years. The disease most often occurs in young women. The accuracy of preoperative diagnosis using abdominal MRI enhanced scans is significantly higher than with enhanced CT. Surgical resection is the preferred treatment and results in good prognosis, high postoperative survival rate, and low rates of recurrence and metastasis. Reoperation after recurrence can still have good therapeutic effect.